Multidrug resistance factor - glycoprotein P in rheumatoid arthritis
نویسندگان
چکیده
منابع مشابه
Multidrug-resistance P-glycoprotein (MDR1) secretes platelet-activating factor.
The human multidrug-resistance (MDR1) P-glycoprotein (Pgp) is an ATP-binding-cassette transporter (ABCB1) that is ubiquitously expressed. Often its concentration is high in the plasma membrane of cancer cells, where it causes multidrug resistance by pumping lipophilic drugs out of the cell. In addition, MDR1 Pgp can transport analogues of membrane lipids with shortened acyl chains across the pl...
متن کاملOverexpression of P-glycoprotein on fibroblast-like synoviocytes in refractory rheumatoid arthritis patients: a potential mechanism for multidrug resistance in rheumatoid arthritis treatment.
This study aims to investigate the role of P-glycoprotein (P-gp) expression level in drug resistance to disease-modifying anti-rheumatic drugs in refractory rheumatoid arthritis (RRA). We evaluated and compared the expression levels of P-gp in fibroblast-like synoviocyte (FLS) cells in patients with rheumatoid arthritis (RA) and osteoarthritis (OA), and investigated the potential mechanism of P...
متن کاملBromocriptine reverses P-glycoprotein-mediated multidrug resistance in tumor cells.
One of the most important causes of anticancer treatment failure is the development of multidrug resistance (MDR). The main characteristics of tumor cells displaying the MDR phenomena are cross-resistance to structurally unrelated cytotoxic drugs having different mechanisms of action and the overexpression of the MDR1 gene, which encodes a transmembrane glycoprotein named P-glycoprotein (P-gp)....
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Rigol N, Frank NY, Margaryan A, Schatton T, Frank MH. Differential expression of ABCB5 multidrug resistance P-glycoprotein in human breast cancer cell lines. Proceedings of the Department of Defense Breast Cancer Research Program Meeting (Era of Hope), June 8-11, 2005, Philadelphia, PA. 2005:467 Abstract P667.
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ژورنال
عنوان ژورنال: Rheumatology Science and Practice
سال: 2003
ISSN: 1995-4492,1995-4484
DOI: 10.14412/1995-4484-2003-1127